Experimental studies were conducted to evaluate the ameliorating effects of propanolic extract of Trigonella foenum graecum (Fenugreek) seeds in ovarian hormone deficiency induced hyperlipidemia in comparision with atorvastatin. Thirty female wistar rats were divided into five groups i.e., group I – normal control (sham operated), group II – ovariectomized rats (OVX), group III – OVX+Fenugreek extract (1 g/kg b.wt), group IV – OVX+Fenugreek (4 g/kg b.wt) and OVX+Atorvastatin (1.2 mg/kg b.wt p.o.). Body weights were taken at weekly interval. Blood was collected from 8 h fasted animals for the estimation of serum biochemical profile (Lipid profile). There was a significant (p<0.05) increase in the serum total cholesterol and non-HDL cholesterol in group II than other groups. Serum HDL concentrations significantly (p<0.05) increased in groups III, IV and V w.r.t group II. There was a significant (p<0.05) increase in the uterine weights in groups III and IV compared to group II and group V. The liver lipid profile revealed significant (p<0.05) decrease in total lipids, total cholesterol and phospholipids in groups III and IV compared to group II. Liver Triglyceride levels in the liver significantly (p<0.05) increased in group I than group II where as there was no much significant difference among other groups.
Loading....